“Sma3s (Sequence massive annotator using 3 modules) is an easy-to-use tool for high throughput annotation that provides both accuracy and broad applicability for different kinds of sequence datasets such as proteomes or transcriptomes.

Biological sequence annotation is the process of associating biological information to sequences of interest. Annotations can include the potential function, cellular localization, biological process or protein structure of a given sequence, and is of special interest for genomics projects, gene-expression experiments and many other emerging areas of research.

Sma3s is a tool for this important area, which is especially focused on the massive annotation of sequences from any kind of gene library or genome. It provides high levels of prediction accuracy (higher than 80%) with minimal manual input and low computational resource requirements. It is composed of three integrative modules that annotate unknown sequences with increasing difficulty. All three modules use a preliminary exhaustive BLAST search as their starting point, and together generate annotations that are both highly sensitive and specific.

Finally, Sma3s offers results in files that can be easily managed and opened with a spreadsheet program.”

Universidad Pablo de Olavide
Centro Andaluz de Biología del Desarrollo (CABD)

• Antonio J. Pérez Pulido
• Antonio Muñoz Mérida
• Carlos Sánchez
• Casimiro-Soriguer

Sma3s: http://www.bioinfocabd.upo.es/sma3s/
Other tools: http://www.bioinfocabd.upo.es/node/5

bioinfocabd@upo.es